In 2002 my best friend and I spent a month on the road seeing the USA: Moscow, ID>Orlando, FL>Wash. DC>Baltimore, MD>NYC, NY>Hershey, PA>Orlando, FL>Jackson, MS>New Orleans, LA>Orlando, FL>Key West, FL>Orlando, FL, then flew back home to Idaho. All told with side trips we did around 20k miles on a brand new off the lot Ford Explorer.
I've driven to SoCal and back more times than I can count. Vegas a couple times too. Phoenix to Idaho was a long one, all backroads until central Utah. The worst highways/drivers of all? 1. Oregon (poor highways, ridiculously low speed limits, no snowplows), 2. South Carolina (NC and GA I-95 are 6 lanes, SC is 4 lanes. Horrible backups. 3ft between you and the car in front of you? Enough room to be cutoff by another driver.) and 3. Mississippi (gridlock in the middle of nowhere, middle of the day and people use the shoulder as an additional passing lane doing 80mph kicking up rocks on your windshield, WTF!!!).